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Metholone Eye Drops
Generic Name : Fluorometholone USP 0.1%
Therapeutic Class : Ophthalmic Steroid
Dosage form : Eye Drops
Pack Size : 5 ml

Metholone (Fluorometholone) is a synthetic corticosteroid with an excellent anti-inflammatory action with no significant influence on the intraocular pressure. In comparison with other corticosteroids, Fluorometholone is
more rapidly degraded in tissue and therefore has less effect on the intraocular pressure. The anti-inflammatory activity of Fluorometholone is at least 40 times stronger than that of Hydrocortisone. The corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid which is released from membrane phospholipids by phospholipase A2. Fluorometholone inhibits the edema, fibrin deposition, capillary dilation, leukocyte migration, phagocytic activity, capillary proliferation, fibroblast proliferation, deposition of collagen and scar formation associated with inflammation.

Metholone Eye Drops is indicated for the treatment of corticosteroid-responsive inflammatory conditions including:

Acute and chronic non-infectious conjunctivitis and keratitis of allergic origin.
Non-infectious inflammation of the anterior chamber of the eye (including anterior uveitis, episcleritis and scleritis).
Post-operative irritative conditions after strabismus, cataract and glaucoma surgery.

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